Hydroxyproline excretion and collagen catabolism in rats of different age groups.
نویسندگان
چکیده
The amount of hydroxyproline in urine is an index to the catabolism of collagen. Diseases like acromegaly, hyperthyroidism, osteoporesis, Marfan’s syndrome which are characterized by changes in the metabolism of collagen have made the urinary hydroxyproline determinations more valuable for clinical purposes (1). The profile of urinary hydroxyproline excretion during the 24-hr period in normal rats of different age groups and the significance of such a study are described in this paper.
منابع مشابه
Significance of urinary hydroxyproline in man.
Since nearly all of the hydroxyproline of the body is found in collagen, it has been suggested (1, 2) that the urinary excretion of this imino acid may be an important index of collagen metabolism. The origin of urinary hydroxyproline, however, is not definitely established. The isotopic studies of Stetten (3) in rats indirectly suggested that most of the free and peptide hydroxyproline in the ...
متن کاملOestradiol inhibits collagen breakdown in the involuting rat uterus.
1. The earlier observation (Woessner, 1969) of oestradiol inhibition of collagen breakdown is confirmed and extended. Administration of 100mug of oestradiol-17beta/day to parturient rats strongly inhibits the loss of collagen from the involuting uterus. Three experiments show that this effect is due to an inhibition of collagen degradation rather than to a stimulation of collagen synthesis. 2. ...
متن کاملHuman skin collagen from different age groups before and after collagenase digestion; an electron microscopic study.
That some alteration in collagen occurs with age has been indicated by various workers. Young rat tendon (Neuberger and others, 1951) shows a greater radioactive glycine turnover than that of adult animals. Similar findings were reported in the skin of rats (Neuberger and Slack, 1953) and rabbits (Harkness and Neuberger, 1952). Under the electron microscope the collagen fibres in newborn rat sk...
متن کاملThe quantitative relationship of urinary peptide hydroxyproline excretion to collagen degradation.
To determine the quantitative relationship of urinary hydroxyproline peptide excretion to collagen breakdown, known quantities of radioactive hydroxyproline peptides were administered to unlabeled animals and excertion of radioactivity in respiratory carbon dioxide, urine, and feces was measured. The major routes of excretion of collagen peptide metabolites were respiratory carbon dioxide (75%)...
متن کاملRelationship between body collagen and urinary hydroxyproline excretion in young rats fed on a low-protein or low-calorie diet.
I . Hydroxyproline was determined in urine, carcass, and skin of young rats fed on lowprotein and low-calorie diets. 2. Protein and calorie deprivation in young rats resulted in a marked fall in the soluble as well as insoluble collagen content of the skin. 3. The collagen content of the carcass (excluding skin) was slightly greater in the deficient rats than in the weanling rats, but very much...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Biochemical medicine
دوره 24 1 شماره
صفحات -
تاریخ انتشار 1980